Arginine, Is This Natural Viagra?

Recent studies have indicated that the dietary supplement L-Arginine works in your body to produce a compound, Nitric Oxide which is used by the male reproductive system to stimulate an erection. The compound, L-Arginine, is a naturally occurring amino acid that is found in our muscle and cell tissue. Although our diets provide a fair amount of this amino acid, dietary supplementation has been shown to be effective in treating low levels of erectile dysfunction.

Subsequently, Arginine seems to be the body’s natural Viagra.
The supplement itself seems to be effective, and vitamin companies are fighting to develop products to exploit its effectiveness. Many nutritional products that now boast treatment of erectile dysfunction contain high levels of Arginine with a myriad of other compoundsRead More>>

Andropause and Erectile Dysfunction

One of the signature symptoms of Andropause is erectile dysfunction (ED). An embarrassing, nerve-wrecking experience, ED is when a male cannot perform for his female partner. In layman’s terms, it is the inability to have an erect penis during sexual activity.

It is the primary issue amongst men in regards to their sex lives. Let’s become acquainted with how a full erection works and why this condition exists.

Men under the influence of Andropause have erectile dysfunction no matter what’s on their mind. Thinking of a nude Playboy centerfold model would likely induce pleasant and sexual thoughts into a man. Sexual thoughts, however detailed or brief they may be, are produced in the brain. After all, the brain is responsible for thinking. These sexual thoughts directly spark nerve signals down through the spinal cord and into the muscles of the penis. These nerves send a flow of blood running through the arteries in the penis while it is in a relaxed state, building pressure.

A man without Andropause can have a constant, steady flow of blood flowing to his penis arteries in a good amount. The more blood that flows down there, the harder and longer your erection will be! When sexual thoughts creep out of your mind and you’re focused on another activity, your penis returns to its relaxed state. We can guess Andropause sufferers are going to have to do something Read More>>

Do erectile dysfunction drugs causes NAION ?

On July 8, 2005 the FDA ordered warnings be put on the package insert labels of Viagra, Cialis, and Levitra to the effect that some users of these impotence drugs -- or erectile dysfunction (ED) drugs -- have developed NAION, a form of blindness. At the same time, however, the FDA stated that it is impossible at present to know if NAION is a side effect of these ED drugs, or an unrelated medical condition.

NAION is considered one of the most common causes of sudden vision loss in older people, with anywhere from 1,000 to 6,000 cases a year, also NAION is one of the most common causes of unexpected or sudden vision loss in older Americans. So question arises here is what exactly is the NAION? and is there a risk from taking erectile dysfunction drugs?

What is NAION and what is happening inside the body to cause damage to  sight?

NAION is an acronym for Nonarteritic Anterior Ischemic Optic Neuropathy. Well, basically, the optic nerve is a nerve that connects the eye to the brain. That's how we see.

The optic nerve has tiny blood vessels that perfuse it and that's how it gets its blood supply and oxygen for it to function properly.The condition generally starts in one eye and can cause complete blindness if both eyes are affected. Those who have poor eyesight appear to have the highest chances for developing NAION.

Is there a risk from taking erectile dysfunction drugs?

It is possible that in certain individuals the drugs could potentially to  this. For example, one theoretical mechanism -- which hasn't been proven, but it is a possibility -- is we know these drugs in some patients lower the blood pressure overall in the body. And it's possible that as the drug lowers the blood pressure, the blood flow through the tiny blood vessels in the optic nerve may be temporarily diminished. And during that time, the optic nerve may suffer damage. Now, again, this is not a definite mechanism, it's just a proposed possible mechanism for why this may occur.

Read More

Cause of diabetes-related erectile dysfunction is clarified by Johns Hopkins researchers

10 Aug 2005

A new study from the Brady Urological Institute at Johns Hopkins suggests an over-supply of a simple blood sugar could be a major cause of erectile dysfunction in diabetic men.

Researchers have found that one particular simple sugar, present in increased levels in diabetics, interferes with the chain of events needed to achieve and maintain erection and can lead to permanent penile impairment over time. The results, which have implications for new types of erectile dysfunction treatments targeting this mechanism of erection, are described in the August 16 issue of the Proceedings of the National Academy of Sciences.

Previous research had shown that diabetic erectile dysfunction was partially due to an interruption in an enzyme that starts the chain of vascular events leading to an erection. The Hopkins team suspected O-GlcNAc, a blood sugar present in hyperglycemic (high blood sugar) circumstances, to be that interrupting factor.

"We were interested to determine whether high glucose in mellitus modifies the endothelial nitric oxide synthase (eNOS) enzyme, which is responsible for the achievement and maintenance of erection," says Biljana Musicki, Ph.D., lead investigator of the study and a research associate in the Brady Urological Institute.

Erectile dysfunction is a common problem for more than half of men with diabetes. Musicki says that an estimated "50 percent to 75 percent of diabetic men have erectile dysfunction to some degree, [a rate] about threefold higher than in non-diabetic men." This is not the same type of erectile dysfunction seen in non-diabetics, and it is less effectively treated with conventional drugs like Viagra.

The study examined rats with type 1 mellitus as well as the overall mechanism of erection. "Erection begins when a sexual stimulus activates the enzyme neuronal nitric oxide synthase (nNOS) that causes short-term release of nitric oxide (NO) at the nerve endings in the penis," Musicki explains.Read More>>

UPDATE 1-Icos quarterly loss narrows on Cialis sales

NEW YORK, Aug 4 (Reuters) - Icos Corp. (ICOS.O: Quote, Profile, Research) on Thursday reported a smaller quarterly loss as growing sales of Cialis, the erectile dysfunction drug it shares with Eli Lilly and Co. (LLY.N: Quote, Profile, Research), helped offset marketing costs.

The biotechnology company posted a net loss of $22.6 million, or 35 cents per share, compared with a loss of $51.9 million, or 82 cents a share, a year ago.

Analysts on average expected a loss of 38 cents per share, according to Reuters Estimates.

Bothell, Washington-based Icos said it expects its full-year net loss to be $1.20 to $1.28 per share.

The company forecast 2005 worldwide Cialis sales of $775 million and said it expects selling, general and administrative costs to decline in the second half of the year.

Sales of Cialis, the Viagra rival that boasts effectiveness for up to 36 hours, rose 39 percent to $190.9 million for the quarter.

Icos revenue for the second quarter was $18.1 million, up from $17.9 million a year ago.

Marketing costs rose to $10.5 million, from $10.1 million a year ago.

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The Surprising Impact OF Viagra On Love And Relationships.

In 1998, Viagra was first introduced to the world, and it is fair to say
that the world has not been the same since. The impact of this
medication has been enormous, not just in the narrow area of treating
erectile dysfunction (ED) for which it was approved, but also in
the way we think of sex and sexuality, and even in the realm of
relationships between men and women.

Millions of men in the United States have tried Pfizer’s wonder
drug, sildenafil, better known as Viagra, and there are thus millions
of women who have also seen its effects on their husbands,
boyfriends, and lovers. Many other millions of men and women
wonder about whether Viagra can offer a solution for their own
sexual and emotional problems or for the problems of their partners.
We human beings are sexual animals, after all. And unfortunately,
our sex lives are not always the way we want them to be. So
it’s no surprise that when sex goes sour, relationships suffer in other
ways as well.

Diabetes,Impotence, and Viagra

Approximately 8.7 million, or 8.7% of all men over the age of 20 in the United States have diabetes.The most life-threatening consequences of diabetes are heart disease and stroke, which strike people with diabetes more than twice as often as they do others. Other complications of diabetes include blindness,impotence, kidney disease, and amputations.
Millions of men suffer from impotence, and it is more common among men with diabetes than others. While it is estimated that 15-25% of men experience erectile dysfunction by the age of 65, it has been reported to affect 50-60% of men with diabetes over the age of 50.

How Diabetes related to Impotence
The most common cause of impotence in men with diabetes is damage to his nervous system.Nerves carry messages back and forth between the brain and other parts of the body. All of your nerves together make up the nervous system.Some nerves tell the brain what is happening in the body. For example, when you step on a tack, the nerve in your foot tells the brain about the pain.Other nerves tell the body what to do. For example, nerves from the brain tell your stomach when it is time to move food into your intestines.

FDA Scientist Warned of Viagra-Blindness Link: Report

More than a year before news broke that the erectile dysfunction drug Viagra was possibly linked to a rare form of blindness, a U.S. Food and Drug Administration safety officer alerted superiors to the possibility, the Washington Post reported Friday.

The unidentified safety officer had been monitoring adverse event reports and told supervisors in April 2004 that doctors and users should be warned of the findings, she reportedly told congressional investigators. But the FDA issued no public warnings or changes to the drug's label until a scientific journal reported last month of the possible link, the newspaper said.

On Monday, Pfizer issued a statement saying it had no evidence in trials involving 13,000 people of a link between Viagra and a form of blindness called non-arteritic anterior ischemic optic neuropathy (NAION). That followed a report in last month's Journal of Neuro-Ophthalmology, which examined seven cases where men suffered NAION within 36 hours of taking Viagra, the Post said.

The FDA has said it has 38 reports of NAION among Viagra users and five additional reports among users of other impotence drugs, the newspaper said.

In response to the latest report, Consumer's Union, publisher of Consumer Reports, renewed a call for congressional reform of the FDA's drug monitoring system. "The fact the agency responsible for drug safety knew for a year that Viagra was linked to blindness, but did nothing with that information, is a clear indication that the system is broken," a spokesman said in a prepared statement.

Source:HealthDay.com

76 percent of men and 29 percent of women think about sex once or more a week (Free Times)

In the 1980s, researchers in England were looking for a new drug to treat angina, a painful and chronic tightening of the chest.

They had plenty of volunteers. The science made sense. Money wasn't a problem. But researchers reviewing the data didn't see the promising results they had hoped. After no measurable improvement, researchers called the study quits and asked participants to return the unused medicine. The women complied. The men didn't.

Pfizer Insists Viagra Doesn't Cause Blindness

AP
06/28/05 9:17 AM PT

Pfizer said it is the company's understanding that the FDA has asked that similar information be included in the labels of all oral erectile dysfunction medicines. The FDA reported there were instances of NAION among those taking Cialis as well as Levitra.

Pfizer said that a review concluded that Viagra doesn't increase patients' risk of blindness but that it is still working with federal regulators to update the drug's label to reflect rare reports of vision loss.

Last month, the U.S. Food and Drug Administration said it had 38 reports of blindness caused by a a condition called NAION or non-arteritic anterior ischemic optic neuropathy among users of Viagra.

What is Silagra?
Silagra is the brand name for Sildenafil Citrate. It’s a medicine that helps men with erectile dysfunction (ED) have sexual intercourse again.

How does Silagra work?
Silagra dilates the arteries in the penis and thus allows filling of blood into sinusoids (small spaces in the penis). As the penis hardens, the veins are compressed restricting the blood flow out of the penis. This filling of blood into the penile space causes an erection.

How well does Silagra work?
Four out of five men who take Silagra show an improvment with erections, regardless of age and how long they have had ED. 

How should I take Silagra?
Take one tablet one hour before you plan to have sex. Don’t take more than one tablet in 24 hours. The medicine comes in tablets of 25mg, 50mg, and 100mg. Most patients can start with 50mg. Even if you take Silagra, you still need physical and mental stimulation and desire to have an erection. If your first dose of Silagra does not help, Call your doctor. Your doctor may want to change your tablet strength.

What are the side effects of Silagra?
Silagra has some common side effects.
• Headache
• Flushing (face and upper body turning red and warm)
• Stomach upset
• Running nose
• Vision changes ( Things look blue)
Headache is the most common side effect. Vision change are least common. Talk to your doctor if you have any side effects with silagra that bothers you.

Can everyone use Silagra?
You should not use Silagra if you take any of these forms of nitrates:
• Isosorbide Mononitrate (brand names: Monotrate, Vasotrate, Ismo, Imdur, Angicor)
• Isosorbide dinitrate (brand names: Sorbitrate, Isordil)
• Sublingual nitroglycerin tablets or spray (Angised, Angispan, GTN spray)
• Transdermal nitroglycerin patches or ointments (brand names: Top nitro, Nitroderm TTS, Myovin)
Please Note: the above is not a comprehensive list and mentions only some commonly used brands. If you are not sure of the medicine you are taking, you should consult your doctor.

Can I take Silagra after food?
Yes, but high fat meals should be avoided before taking Silagra to have better response.

Can I take Silagra with alcohol?
The consumption of alcoholic beverages can temporarily impair the ability to get and keep a sustained erection. To achieve maximum results while using Silagra, you should not drink large amounts of alcohol before taking the medication.

Will Silagra work as soon as I take it?
For the best results, take Silagra about one hour before engaging in sexual activity. Silagra is designed to last between 30 minutes and four hours for most patients. Ultimatley, Silagra can help you get an erection and maintain that erection if you are sexually aroused.

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